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TikTok is inching closer to a potential ban in the US. So what's next?Closing marks second significant acquisition from RA Capital's Raven incubator in 2024, and first acquisition of a company built by Raven from a technology platform in-licensed from a large pharmaceutical company BOSTON , Dec. 11, 2024 /PRNewswire/ -- RA Capital Management, LP (RA Capital), a multi-stage investment manager dedicated to evidence-based investing in public and private healthcare, life sciences, and planetary health companies, today announced that AbbVie has closed its $1.4 billion acquisition of RA Capital's portfolio company Aliada Therapeutics. Aliada's lead investigational asset is ALIA-1758, an anti-pyroglutamate amyloid beta (3pE-Aβ) antibody, which is in development for the treatment of Alzheimer's disease and is currently in a Phase 1 clinical trial. ALIA-1758 utilizes a novel blood-brain barrier-crossing technology that enhances delivery of targeted drugs into the central nervous system. Johnson & Johnson (through its venture capital arm, Johnson & Johnson Innovation – JJDC, Inc.), RA Capital, and Raven (RA Capital's healthcare incubator) co-founded Aliada and co-led the series seed financing in 2021 to advance the MODELTM platform created by Johnson & Johnson scientists that was licensed to Aliada at its inception. "Congratulations to the Aliada and AbbVie teams and our fellow investors on the close of this transaction," said Joshua Resnick , MD, Senior Managing Director at RA Capital Management and former board director at Aliada. "The acquisition of Aliada is the second significant acquisition of a Raven-grown company this year, joining Novartis' $1 billion upfront acquisition of radiopharmaceutical developer Mariana Oncology in May." "Delivering therapeutics across the blood-brain barrier with a low-volume, subcutaneous injection would be revolutionary for treating Alzheimer's disease and other neurological disorders, and has long been a dream in the field," said Laura Tadvalkar , PhD, Managing Director at RA Capital Management and former board chair at Aliada. "We look forward to following ALIA-1758's progress through the clinic, as AbbVie advances this important medicine for Alzheimer's disease patients." About Raven Raven is RA Capital Management's healthcare incubator. Raven's experienced team of scientists, operators, and innovators bring deep sector expertise, insight and executional capabilities across therapeutics, diagnostics, devices, and services. Raven builds companies: from originating and incubating new ideas to accelerating compelling innovations and rejuvenating promising assets. About RA Capital Founded in 2004, RA Capital Management is a multi-stage investment manager dedicated to evidence-based investing in public and private healthcare, life sciences, and planetary health companies. RA Capital creates and funds innovative companies, from private seed rounds to public follow-on financings, allowing management teams to drive value creation from inception through commercialization and beyond. RA Capital's knowledge engine is guided by our TechAtlas internal research division, and Raven, RA Capital's company creation team, offers entrepreneurs and innovators a collaborative and comprehensive platform to explore the novel and the re-imagined. RA Capital has more than 175 employees and over $10 billion in assets under management. The companies presented herein were selected to demonstrate a potential successful outcome of a company being incubated within our Raven incubator. They are not intended to represent a complete picture of RA Capital's portfolio, its exposures, risks or potential for positive or negative returns. Past performance is not indicative of future results. View original content to download multimedia: https://www.prnewswire.com/news-releases/ra-capital-management-announces-close-of-1-4-billion-acquisition-of-aliada-therapeutics-by-abbvie-302329567.html SOURCE RA Capital Management, LP
City slumped to their seventh defeat in 10 games in all competitions as they were beaten 2-0 at Juventus in their latest European outing on Wednesday. Second-half goals from Dusan Vlahovic and Weston McKennie at the Allianz Stadium left Guardiola’s side languishing in 22nd place in the standings. With just two games of the league phase remaining, a place in the top eight and automatic last-16 qualification looks beyond them and they face a battle just to stay in the top 24 and claim a play-off spot. City manager Guardiola said: “Of course I question myself but I’m stable in good moments and bad moments. “I try to find a way to do it. I’m incredibly honest. If we play good (I say) we played good and today I thought we played good. “Our game will save us. We can do it. We conceded few chances compared to the Nottingham Forest game that we won. We’re making the right tempo. “We missed the last pass, did not arrive in the six-yard box (at the right time) or have the composure at the right moment. “But I love my team. This is life, it happens. Sometimes you have a bad period but I’m going to insist until we’re there.” City now face a crunch trip to Paris St Germain, who are also at risk of failing to qualify, next month. Guardiola accepts the top 24 is now the only aim. He said: “It’s the target. We need one point or three points. We go to Paris to try to do it and the last game at home.” Veteran midfielder Ilkay Gundogan said after the game he felt City were suffering from a loss of confidence but Guardiola dismissed his player’s comments. “I am not agreeing with Ilkay,” he said. “Of course it is tough but, except one or two games in this period, we’ve played good.” City now face a further test of their resolve as they host rivals Manchester United in a derby on Sunday. Gundogan told TNT Sports: “It (confidence) is a big part of it. That’s a mental issue as well. “You can see that sometimes we miss the ball or lose a duel and you see that we drop immediately and lose the rhythm. They (the opponents) don’t even need to do much but it has such a big effect on us right now. “Even more you have to do the simple things as good as possible and create and fluidity, then it’s work hard again. This is how you get confidence back – do the small and simple things, (but) in crucial moments at the moment we are always doing the wrong things.” Juventus coach Thiago Motta was pleased with the hosts’ performance, which boosted their hopes of making the top eight. “It was a deserved victory,” he said. “We had to defend as a team and be ready to attack with quality. “We have shown we can compete at this level and now we have to do it consistently.”Rico Carty, who won the 1970 National League batting title with the Atlanta Braves, dies at 85Biden facing pressure to grant additional pardons
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Breaking News Don't miss out on the headlines from Breaking News. Followed categories will be added to My News. A newborn baby has been rushed to hospital with serious head injuries after two teens allegedly stormed a home in the Northern Territory. Emergency services were called to the home in Larapinta after reports two males had unlawfully entered the property about 2.30pm on Wednesday. Police allege one man threatened a woman who was holding her two-month-old infant before assaulting her with a blunt weapon, while another searched the home. The two youths allegedly fled the scene with the woman’s handbag and vehicle keys but were located by police a short time later, with one of the men placed under arrest. police received reports that two males had allegedly unlawfully entered a residence on Bokhara Street, Parapinta about 2.30pm. A second youth allegedly fled in a vehicle but after a short pursuit was also arrested by Northern Territory police. The woman, who was at home with four children at the time, was rushed to Alice Springs Hospital. The infant sustained a serious head injury and was also taken to Alice Springs, before being flown to Adelaide for further treatment where they remained in a stable condition. Detective Superintendent Regional Crime Paul Lawson said police responded “en masse” to the alleged incident, and thanked the first responders who attended. Detective Superintendent Regional Crime Paul Lawson said police responded “en masse”/ Picture: NT Police “This is an absolutely shocking incident. I’m shocked. The community is shocked. First responders are shocked,” he said in a social media video. “Our thoughts go out to the victims of this incident, their families. I cannot even think about what they’re going through”. Two males, aged 16 and 17, have since been charged over the alleged attack, including with aggravated burglary and robbery. They also face charges of unlawfully causing serious harm, aggravated assault, and theft, and are due in court on Thursday. Originally published as Newborn, mum rushed to hospital after teens allegedly attack home More related stories Careers ‘Privilege’: Sonny Bill’s shock career move A global sports star known for his deep faith and “passion for social equity” has made a surprising career change. Read more Breaking News ‘If I refuse?’: Violent man’s wild question A violent offender is back in the community, but a wild exchange with a Supreme Court justice suggests he might struggle to fit in. Read moreEngland wicketkeeper Jordan Cox has been ruled out of the three-test series against New Zealand after fracturing his thumb in a net session during a tour match in Queenstown. Cox was set to make his test debut in the series opener in Christchurch, which starts on Thursday, as cover for regular gloveman Jamie Smith, who is skipping the tour for the birth of his first child. "I'm gutted for Jordan. He has been shaping up nicely, both with the bat and gloves, since we got to New Zealand," coach Brendon McCullum said in a team statement on Monday. "That's sport, and unfortunately, these things happen. We will get around him and look after him. He is resilient, and his time will come at some point in the future." Ollie Pope took the gloves for Sunday's second and final day of the tour match against the New Zealand Prime Minister's XI and a replacement for Cox will be announced "in due course", the team said.
NEW ORLEANS (AP) — A southeast Louisiana official has been accused of committing perjury for failing to disclose information related to a controversial grain terminal in the state's Mississippi River Chemical Corridor in response to a lawsuit brought by a prominent local climate activist. St. John the Baptist Parish President Jaclyn Hotard denied in a deposition that she knew her mother-in-law could have benefited financially from parish rezoning plans to make way for a 222-acre (90-hectare) grain export facility along the Mississippi River. Hotard also said in court filings, under oath, that no correspondence existed between her and her mother-in-law about the grain terminal, even though her mother-in-law later turned over numerous text messages where they discussed the grain terminal and a nearby property owned by the mother-in-law's marine transport company, court records show. The text messages were disclosed as part of an ongoing lawsuit filed by Joy Banner, who along with her sister, Jo Banner, successfully led efforts to halt the $800 million grain terminal earlier this year. It would have been built within 300 feet (91 meters) of their property and close to historic sites in the predominantly Black community where they grew up. The legal dispute is part of a broader clash playing out in courts and public hearings , pitting officials eager to greenlight economic development against grassroots community groups challenging polluting industrial expansion in the heavily industrialized 85-mile industrial corridor between Baton Rouge and New Orleans often referred to by environmental activists as “Cancer Alley.” “We are residents that are just trying to protect our homes and just trying to live our lives as we have a right to do,” Banner said in an interview with The Associated Press. The Banner sisters gained national attention after cofounding the Descendants Project, an organization dedicated to historic preservation and racial justice. In the text messages turned over as part of Joy Banner's lawsuit, Hotard, the parish president, says that she wished to “choke” Joy Banner and used profanities to describe her. Hotard also said of the Banner sisters: “I hate these people.” Hotard and her attorney, Ike Spears, did not respond to requests for comment after Tuesday's filing. Richard John Tomeny, the lawyer representing Hotard's mother-in-law, Darla Gaudet, declined to comment. Banner initially sued the parish in federal court in December 2023 after Hotard and another parish councilman, Michael Wright, threatened her with arrest and barred her from speaking during a public comment period at a November 2023 council meeting. “In sum: a white man threatened a Black woman with prosecution and imprisonment for speaking during the public comment period of a public meeting,” Banner's lawsuit says. It accuses the parish of violating Banner's First Amendment rights. Wright and his lawyer did not respond to requests for comment. Hotard and Wright have disputed Banner's version of events in court filings. At the November 2023 meeting, Banner attempted to highlight Hotard's alleged conflict of interest in approving a zoning change to enable the grain export facility's construction. Banner had also recently filed a complaint to the Louisiana Board of Ethics against Hotard pointing out that her mother-in-law allegedly would benefit financially because she owned and managed a marine transport company that had land “near and within” the area being rezoned. In response to a discovery request, Hotard submitted a court filing saying “no such documents exist” between her and her mother-in-law discussing the property, the grain terminal or Joy Banner, according to the recent motion filed by Banner's attorneys. Hotard also said in her August deposition that she had “no idea” about her mother-in-law's company's land despite text messages showing Hotard and her mother-in-law had discussed this property less than three weeks before Hotard's deposition. Banner's lawsuit is scheduled to go to trial early next year. Brook is a corps member for The Associated Press/Report for America Statehouse News Initiative. Report for America is a nonprofit national service program that places journalists in local newsrooms to report on undercovered issues. Follow Brook on the social platform X: @jack_brook96
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