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Special counsel moves to abandon election interference and classified documents cases against TrumpBy TravelPulse (TNS) While 2024 was a year that brought about significant, continued post-pandemic recovery for the travel industry, it was also a period of time marked by instability in some locations around the world. From attacks on the rail lines during the Paris Olympics to the ongoing conflicts in the Middle East, not to mention the war in Ukraine, the global travel realm in 2024 was fraught with challenges. It is against this backdrop that the international security and medical services provider Global Guardian recently released its 2025 Global Risk Map. Published annually, the map is meant to help travelers better understand the current global risk landscape. In order to develop its guidance, experts at Global Guardian assess a long list of country-specific security risk factors and indicators, including crime, health, natural disasters, infrastructure, political stability, civil unrest and terrorism. For 2025, Global Guardian’s assessment results underscore the reality that disruption globally and domestically continues to increase, and now more than ever travelers need to be prepared when exploring the world. As part of the latest assessment, Global Guardian highlighted a handful of specific global regions that are at particular risk of destabilization over the next year and beyond. Here’s a closer look at those regions, along with insights from Global Guardian CEO Dale Buckner, who recently spoke with TravelPulse at length about the risks travelers may face in 2025. Here are the regions at risk of destabilization in 2025: Israel’s existential battle against Iran is set to continue into 2025, says the Global Guardian report. “In July 2024, Israel assassinated Hamas’ political leader, Ismail Haniyeh, in an Iranian Revolutionary Guard Corps (IRGC) safehouse in Tehran, and Iran has pledged revenge,” the report explains. “This comes as Iran and its web of regional proxies took their war on Israel out of the shadows and into the open following October 7, 2023, with seven live fronts.” Global Guardian also predicts that Israel’s regional war will shift from Gaza to the West Bank and Lebanon in the year ahead, heightening tensions with Hezbollah, while Houthi attacks on commercial shipping in the Red Sea and Indian Ocean will persist. The report adds that as “we enter 2025, Israel may assess that its strategic window to prevent a nuclear Iran is rapidly closing and choose to act.” The ongoing civil war in Sudan between the Sudanese Armed Forces (SAF) and the Rapid Support Forces (RSF), is also of concern, according to Global Guardian’s risk analysis. The conflict “has created a dire humanitarian situation with ethnically motivated violence on the rise,” says the report. Some of the areas of concern in the Latin American region include Venezuela and Mexico, according to Global Guardian. The risk in Venezuela is tied to the country’s long-standing territorial dispute with neighboring Guyana, says the report. “Since 2019, the U.S. Department of State withdrew all diplomatic personnel from U.S. Embassy Caracas and suspended all operations,” explains Buckner. “Violent crimes, such as homicide, armed robbery, kidnapping, and carjacking, are common in Venezuela. Shortages of gasoline, electricity, water, medicine, and medical supplies continue throughout much of Venezuela. Simply put, Venezuela is one of the most dangerous countries in the world for Western travelers and should be avoided.” In Mexico, meanwhile, the problems include drug cartel-related violence and theft, among other issues, says the report. Mexico recently inaugurated its first female president, Claudia Sheinbaum, and like her predecessors she will face challenges “reining in cartel violence, corruption, extortion, theft and kidnapping,” says the report. “As such, security continues to be a top concern in Mexico’ ” says the report, which categorizes Mexico as “high risk” when it comes to travel for 2025. Countries classified as high risk experience regular conflict, criminal activity or civil unrest — and have not effectively managed those risks. The Global Guardian report also suggests there may be heightened risks in Mexico now that Donald Trump has been reelected U.S. president. “Bilateral relations between the U.S. and Mexico could dramatically deteriorate. Trump has promised a mass deportation operation, which could sour relations between the U.S. and Mexico, increasing risks to businesses operating in Mexico,” the report adds. Asked to comment on Mexico’s high-risk designation, Buckner stressed that the situation in the country is extremely nuanced, adding that it’s a vast oversimplification to call the entire country high risk. “There are pockets of Mexico that are wildly safe and wonderful to visit and people shouldn’t hesitate to go,” Buckner told TravelPulse. “And there are also pockets that are unsafe and dangerous.” The good news, added Buckner, is that Mexico’s new president is focusing a great deal of effort and energy on addressing the problems surrounding drug cartels, which are the source of a great deal of the risk. Buckner was quick to add however, that as long as there’s demand for drugs, the drug cartel situation is likely to remain problematic. “The U.S. is driving the drug demand — we consume more drugs then the rest of the world,” explained Buckner. “It’s really overly simplified to paint Mexico as the bad guy, because if there wasn’t demand, we wouldn’t need the supply. But the demand is real and violence comes with that.” Representatives for Global Nexus, a government and public affairs consultancy that advises travel and tourism companies and interests in Southern Mexico, told TravelPulse that while drug-related violence has been known to occur, it involves members of the drug cartel targeting each other, they’re not targeting tourists. “There is an ongoing battle between small drug vendors who use the beach to sell product to tourists hanging out on the beach,” explained Ruben Olmos, Global Nexus president and CEO, in reference to the Quintana Roo region, which is popular with tourists. “There have been cases where gunfire has been exchanged between these groups. They are targeting themselves. They are fighting over ‘This is my beach’ and they initiate a shootout.” However, added Olmos, that the U.S. State Department’s risk categorization for Quintana Roo (which is separate from the Global Guardian risk assessment) has not changed. Located on the State Department’s Mexico page, the risk assessment for Quintana Roo remains in the “Exercise Increased Caution” category, which is below the top risk categories of “Do Not Travel” and “Reconsider Travel.” The Exercise Increased Caution designation means “Be aware of heightened risks to safety and security,” explains the State Department’s website. Olmos also pointed out that Mexico is the only country that has a map on the U.S. State Department website that covers every single state in the country, providing details for travelers about which states are safest. In June 2024, thousands of young people took to the streets in Kenya to protest a controversial tax bill. The protesters were met with heavy-handed policing, including the use of live fire and mass arrests, says the Global Guardian risk report. Despite the local security response, protests continued. The success and tenacity of the Kenyan movement has triggered similar protests or dissent in other countries including Uganda, Tanzania, South Africa, and Nigeria, says Global Guardian. That is just a portion of the risk Global Guardian sees for Sub-Saharan Africa over the course of 2025. “With multiple conflicts escalating across the continent, aging leaders leaving behind unclear successions, and entrenched regimes with dissipating legitimacy, Sub-Saharan Africa now looks much like the North African and Arab world in the early 2010s,” says the report. “While the dynamic unfolding in Africa might not yet merit the label of “African Spring,” a significant change to the continent’s political status quo is coming.” Several countries received an extreme or high-risk designation on the new Global Guardian risk map for 2025, including more than a few that are popular with leisure travelers or tourists. Extreme risk countries are those that Global Guardian says are “actively engaged in conflict, while also experiencing severe criminal activity and civil unrest.These countries are insecure; state institutions are too weak to manage militant groups or large-scale disasters.” They include Afghanistan, Burkina Faso, Central African Republic, Lebanon, Mali, Niger, Somalia, Ukraine, West Bank, Gaza and Yemen. The current list of high-risk countries, which are countries that experience regular conflict, criminal activity or civil unrest and have not effectively managed those risks, includes Bangladesh, Cameroon, Democratic Republic of Congo, Ecuador, Ethiopia, Guatemala, Honduras, Iraq, Israel, Jamaica, Kenya, Libya, Mexico, Mozambique, Myanmar, Nigeria, Pakistan, Papua New Guinea, South Sudan, Uganda, Venezuela Officials from the Jamaica Tourist Board provided a statement to TravelPulse in response to Global Guardian’s designation of the country. “Last month, Global Guardian, a private security provider, released its 2025 Global Risk Map, which included Jamaica, amongst other destinations,” said the Tourist Board. “It is important to note that the crime rate against visitors is notably low at 0.01% and the majority of Jamaica’s tourism product remains unaffected.” The country’s tourism officials added that Jamaica has welcomed 3 million visitors this year and boasts a high repeat visitor rate of 42%. “The island is consistently ranked among the top destinations for international travel and visitors continue to come with confidence to enjoy all that Jamaica has to offer,” the statement adds. When it comes to Jamaica, Buckner offered similar comments to those of Mexico, noting that the situation is impacted by drug-related violence and the experience on the ground is nuanced and cannot be painted with a broad brush. “In the same vein as Mexico — Jamaica can be a wonderful place to visit,” says Buckner. “There are pockets of beauty and low crime and as long as you are careful, it’s a very low threat.” Buckner, a retired Army colonel, maintains that the world is indeed a more risky place heading into 2025. The challenges in the Middle East and Ukraine are at the forefront of the instability, but are hardly the only cause for concern. “Israel has now gone to Gaza and cleaned out Hamas, they’re now moving north into Lebanon, and we are convinced Israel will strike Iran,” Buckner said during an interview that took place prior to Israel’s strike on Iran. “If that occurs you are going to see violence across the Middle East.” “But there are over 100 conflicts across the globe,” continues Buckner. When you combine that reality with other challenges the world is currently grappling with, including the destabilizing influences of climate change, there are plenty of risks for travelers to bear in mind when planning a journey for the coming year. He wraps up by offering a few tips for travelers, a check-list of sorts, to work through when planning or considering travel to a specific country in 2025: — If you don’t know who to call or how you are going to negotiate if someone is kidnapped, you shouldn’t go there. — Consumers need to read the fine print on travel insurance because it does not cover war zones, terrorism or natural disasters, says Buckner. And travelers are often surprised and find out too late that these types of events are not covered. — If you get stuck or stranded, if you don’t know who you are going to call to get you out of that situation, know what organizations locally or internationally are available to help you. ©2024 Northstar Travel Media, LLC. Visit at travelpulse.com. Distributed by Tribune Content Agency, LLC.
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Business Memoranda: 11/27/2024
Austin, Dec. 08, 2024 (GLOBE NEWSWIRE) -- The S&S Insider report indicates that, “ The Downstream Processing Market was valued at USD 29.35 Billion in 2023 and is projected to reach USD 99.64 Billion by 2032, growing at a compound annual growth rate (CAGR) of 14.60% from 2024 to 2032. ” Accelerating Growth of the Downstream Processing Market The downstream processing market is experiencing rapid expansion, fueled by the surging demand for biopharmaceuticals such as vaccines, monoclonal antibodies, and enzymes. This growth is driven by the rising prevalence of chronic diseases and advancements in biotechnology, which have spurred the development of biologics. With global pharmaceutical industry revenues reaching approximately USD 1.6 trillion in 2023, biopharmaceuticals have emerged as a significant and fast-growing segment. Downstream processing is pivotal in ensuring the efficient purification and recovery of these complex products, promoting further innovation in the field. This innovation is reflected in the adoption of advanced technologies like single-use systems, membrane chromatography, and continuous processing. By Q1 2023, over 100 approved gene, cell, and RNA therapies, alongside 3,700 therapies in development, underscored the rising need for scalable solutions. These advancements enhance operational efficiency, reduce costs, and support the increasing global demand for biologics. Download PDF Sample of Downstream Processing Market @ https://www.snsinsider.com/sample-request/2618 Key Players: Merck KGaA (MilliporeSigma) (Viresolve Barrier Filters, ProSep Ultra Plus Protein A Resin) Sartorius Stedim Biotech S.A (Sartobind Membrane Adsorbers, Sartoflow Advanced Systems) Thermo Fisher Scientific Inc. (POROS Chromatography Resins, CaptureSelect Affinity Ligands) Danaher Corporation (Pall Allegro MVP Single-Use System, Cytiva ReadyToProcess Columns) Repligen (OPUS Pre-packed Columns, XCell ATF Systems) 3M Company (Zeta Plus Depth Filters, Emphaze AEX Hybrid Purifiers) Boehringer Ingelheim International GmbH (BIHEX Process Solutions, Biopharmaceutical Contract Services) Corning Corporation (Corning CellCube Systems, X-Series Hollow Fiber Filters) Lonza Group Ltd (Centrifuge Systems, Viral Clearance Services) Dover Corporation (Quattroflow Diaphragm Pumps, Maag Industrial Filtration Solutions) Asahi Kasei (Planova Virus Filters, Microza UF Membranes) Eppendorf AG (Centrifuge 5910 R, BioFlo Bioprocess Controllers) Finesse Solutions Inc. (Thermo Fisher Subsidiary) (SmartVessel Bioreactor, G3Lab Universal Controllers) Purolite Life Sciences (Praesto Protein A Resins, Chromalite Ion Exchange Resins) Tosoh Bioscience (TOYOPEARL Protein A Resins, TSKgel Chromatography Columns) Novasep (BioSC Chromatography Systems, Prochrom Bio Columns) MilliporeSigma (a subsidiary of Merck KGaA) (Durapore Filters, Chromabolt Pre-packed Columns) Waters Corporation (PATROL UPLC Process Analyzer, AutoPurification Systems) PerkinElmer Inc. (LabChip GXII Microfluidics System, QSight 420 Mass Spectrometer) Bio-Rad Laboratories, Inc. (UNOsphere Chromatography Resins, NGC Chromatography Systems) Avantor (VWR) (J.T.Baker High Purity Solvents, Arium Sterile Filtration Units) Spectrum Labs (Repligen subsidiary) (KrosFlo TFF Systems, Hollow Fiber TFF Modules) Meissner Filtration Products (UltraCap Depth Filters, FlexGro Single-Use Assemblies) Downstream Processing Market Report Scope: If You Need Any Customization on Downstream Processing Market Report, I nquire Now @ https://www.snsinsider.com/enquiry/2618 By Application , Antibiotics Dominate While Antibodies Drive Rapid Growth in Downstream Processing Market In 2023, the Antibiotic Production segment captured 34% of the downstream processing market revenue, driven by global demand to combat bacterial infections. Their widespread application in healthcare and agriculture, coupled with mature manufacturing practices, ensures large-scale production and steady revenues. Cost-effective purification methods and antibiotics' essential role in public health further solidify this segment's dominance. The Antibodies Production segment is expected to grow at a CAGR of 16.51% from 2024 to 2032, fueled by rising demand for monoclonal antibodies and biosimilars to treat cancer and autoimmune diseases. Innovations in scalable downstream technologies, such as chromatography and single-use systems, and a robust pipeline of therapies are accelerating growth, highlighting the segment’s expanding prominence in biopharma. By Technique , Chromatography Leads While Solid-Liquid Separation Drives Future Growth In 2023, the Purification By Chromatography segment accounted for 42% of the downstream processing market revenue, owing to its unmatched ability to deliver high-purity biomolecules. Its adaptability for diverse biopharmaceuticals, including monoclonal antibodies and vaccines, has positioned it as a vital industry tool. Ongoing technological advancements have further solidified its role as the most reliable purification method. The Solid-Liquid Separation segment is poised to grow at the fastest CAGR of 16.99% from 2024 to 2032, driven by rising demand for efficient filtration and centrifugation solutions. Its critical role in biologics and cell therapy production, coupled with a shift toward sustainable and cost-effective manufacturing, drives innovation. These factors underline its importance in meeting the evolving needs of the biopharma sector. North America Dominates, Asia Pacific Drives Rapid Growth In 2023, North America accounted for 36% of the downstream processing market revenue, led by its strong biopharmaceutical industry and advanced R&D infrastructure. Substantial investments in manufacturing technologies and the presence of major market players have reinforced its dominance. High demand for biologics and favorable regulatory support further cement its leadership. The Asia Pacific region is set to grow at the fastest CAGR of 16.68% from 2024 to 2032, driven by increasing biopharma investments and expanding healthcare infrastructure. Government initiatives promoting local biomanufacturing and cost-efficient production capabilities are key growth drivers. The region's rising demand for biologics and biosimilars underscores its growing role in the global market. Buy Full Research Report on Downstream Processing Market 2024-2032 @ https://www.snsinsider.com/checkout/2618 Key Developments in the Downstream Processing Market On November 21, 2024, Sartorius Stedim Biotech inaugurated its Center for Bioprocess Innovation in Marlborough, USA, focusing on cell and gene therapy manufacturing with GMP suites set to open in 2025. On November 7, 2024, Thermo Fisher Scientific announced the construction of a 10,000-square-foot Bioprocess Design Center in Hyderabad, India, to advance biotherapeutics manufacturing, opening in early 2025. Table of Contents – Major Key Points 1. Introduction Market Definition Scope (Inclusion and Exclusions) Research Assumptions 2. Executive Summary Market Overview Regional Synopsis Competitive Summary 3. Research Methodology Top-Down Approach Bottom-up Approach Data Validation Primary Interviews 4. Market Dynamics Impact Analysis Market Driving Factors Analysis PESTLE Analysis Porter’s Five Forces Model 5. Statistical Insights and Trends Reporting Regulatory Approvals Technological Adoption Rates Cost Contributions Regulatory Approvals 6. Competitive Landscape List of Major Companies, By Region Market Share Analysis, By Region Product Benchmarking Strategic Initiatives Technological Advancements Market Positioning and Branding 7. Downstream Processing Market Segmentation, by Application 8. Downstream Processing Market Segmentation, by Product 9. Downstream Processing Market Segmentation, by Technique 10. Regional Analysis 11. Company Profiles 12. Use Cases and Best Practices 13. Conclusion Speak with O ur E xpert A nalyst T oday to G ain D eeper I nsights @ https://www.snsinsider.com/request-analyst/2618 [For more information or need any customization research mail us at info@snsinsider.com ] About Us: S&S Insider is one of the leading market research and consulting agencies that dominates the market research industry globally. Our company's aim is to give clients the knowledge they require in order to function in changing circumstances. In order to give you current, accurate market data, consumer insights, and opinions so that you can make decisions with confidence, we employ a variety of techniques, including surveys, video talks, and focus groups around the world.GAINESVILLE, Fla. (AP) — DJ Lagway threw two touchdown passes, Montrell Johnson ran for 127 yards and a score, and Florida upset No. 9 Mississippi 24-17 on Saturday to knock the Rebels out of College Football Playoff contention. The Gators (6-5, 4-4 Southeastern Conference), who topped LSU last week, beat ranked teams in consecutive weeks for the first time since 2008 and became bowl eligible. The late-season spurt provided another vote of confidence for coach Billy Napier, who is expected back for a fourth season. Ole Miss (8-3, 4-3), which entered the day as a 10-point favorite, lost for the first time in four games and surely will drop out of the 12-team playoff picture. The Rebels ranked ninth in the latest CFP and needed only to avoid stumbling down the stretch against Florida and lowly Mississippi State to clinch a spot in the playoff field. But coach Lane Kiffin’s team failed to score in three trips inside the red zone and dropped countless passes in perfect weather. No. 2 OHIO ST. 38, No. 5 INDIANA 15 COLUMBUS, Ohio (AP) — Will Howard passed for two touchdowns and rushed for another, TreVeyon Henderson ran for a score and No. 2 Ohio State beat previously undefeated No. 5 Indiana. All Ohio State (10-1, 7-1 Big Ten, CFP No. 2) has to do now is beat Michigan at home next Saturday and it will earn a return to the Big Ten championship game for the first time since 2020 and get a rematch with No. 1 Oregon. The Ducks beat Ohio State 32-31 in a wild one back on Oct. 12. The Hoosiers (10-1, 7-1, No. 5 CFP) had their best chance to beat the Buckeyes for the first time since 1988 but were hurt by special teams mistakes and disrupted by an Ohio State defense that sacked quarterback Kurtis Rourke five times. Howard finished 22 for 26 for 201 yards. Emeka Egbuka had seven catches for 80 yards and a TD. No. 8 GEORGIA 59, UMass 21 ATHENS, Ga. (AP) — Carson Beck threw four touchdown passes, Nate Frazier ran for 136 yards with three scores and No. 8 Georgia overwhelmed Massachusetts as the Bulldogs tried to protect their College Football Playoff hopes. Georgia (9-2, No. 10 CFP) needed the big offense from Beck and Frazier to rescue a defense that gave up 226 rushing yards. UMass (2-9) played its first game under interim coach Shane Montgomery, the offensive coordinator who retained his play-calling duties after replacing fired coach Don Brown on Monday. Jalen John led the Minutemen with 107 rushing yards and a touchdown. Georgia extended its streak of consecutive home wins to 30, the longest active streak in the Football Bowl Subdivision. No. 10 TENNESSEE 56, UTEP 0 KNOXVILLE, Tenn. (AP) — Nico Iamaleava threw for 209 yards and four touchdowns to lead No. 10 Tennessee to a victory over UTEP. The Volunteers (9-2) overcame a sluggish start to roll up the impressive win. Both teams were scoreless in the first quarter, but Tennessee found its rhythm. Grad student receiver Bru McCoy, who hadn’t caught a touchdown pass this season, had two. Peyton Lewis also ran for two scores. Tennessee’s defensive line, which had no sacks in last week’s loss to Georgia, had three against the Miners. UTEP (2-9) struggled with two missed field goals and three turnovers. Tennessee’s offense came alive with 28 points in the second quarter. In the final four drives of the quarter, Iamaleava completed 11 of 12 passes for 146 yards and touchdowns to Squirrel White, Ethan Davis and McCoy. No. 11 MIAMI 42, WAKE FOREST 14 MIAMI GARDENS, Fla. (AP) — Cam Ward passed for 280 yards and threw two touchdowns to Jacolby George on another record-breaking day, Mishael Powell ran an interception back 76 yards for a touchdown and No. 11 Miami pulled away late to beat Wake Forest. The Hurricanes (10-1, 6-1 Atlantic Coast Conference, No. 8 College Football Playoff) can clinch a berth in the ACC title game with a win at Syracuse next weekend. Ward completed 27 of 38 passes, plus ran for a score. He broke two more single-season Miami records, both of which had been held for 40 years by Bernie Kosar — most passing yards in a season and most completions in a season. Ward now has 3,774 yards on 268 completions this season. Kosar threw for 3,642 yards on 262 completions in 1984. Demond Claiborne had a 100-yard kickoff return for a touchdown for Wake Forest (4-7, 2-5). Claiborne also rushed for 62 yards for the Demon Deacons, and starting quarterback Hank Bachmeier was 8 of 14 passing for 86 yards and a touchdown. No. 13 SMU 33, VIRGINIA 7 CHARLOTTESVILLE, Va. (AP) — Kevin Jennings threw for a career-high 323 yards and two touchdowns and ran for another, and No. 13 SMU clinched a spot in the Atlantic Coast Conference championship game by routing Virginia. Isaiah Smith and Jared Harrison-Hunte each had two sacks to help the Mustangs (10-1, 7-0, No. 13 CFP) extend their winning streak to eight. They would earn an automatic bid into the expanded College Football Playoff by beating 11th-ranked Miami or 17th-ranked Clemson in the ACC title game on Dec. 7 in Charlotte, North Carolina. SMU had to get there first, and Jennings led the way again, bouncing back from an interception and a fumble to complete 25 of 33 passes to six different receivers, including TD tosses to Jordan Hudson and Matthew Hibner. Brashard Smith provided a little balance on offense, running for 63 yards and his 13th touchdown of the season. SMU’s defense overwhelmed UVa’s offensive line, sacking Anthony Colandrea nine times and allowing the Cavaliers (5-6, 3-4) just 173 yards. Special teams contributed, too, with Roderick Daniels Jr. returning a punt 48 yards and Collin Rogers making two field goals. No. 24 ILLINOIS 38, RUTGERS 31 PISCATAWAY, N.J. (AP) — Luke Altmyer found Pat Bryant for a catch-and-run, 40-yard touchdown pass with 4 seconds left, sending No. 24 Illinois to a wild victory over Rutgers. Illinois (8-3, 5-3 Big Ten) was down 31-30 when it sent long kicker Ethan Moczulski out for a desperation 58-yard field goal with 14 seconds to go. Rutgers coach Greg Schiano then called for a timeout right before Moczulski’s attempt was wide left and about 15 yards short. After the missed field goal was waved off by the timeout, Illinois coach Bret Bielema sent his offense back on the field. Altmyer hit Bryant on an in cut on the left side at the 22, and he continued across the field and scored untouched in a game that featured three lead changes in the final 3:07. Rutgers (6-5, 3-5) gave up a safety on the final kickoff return, throwing a ball out of bounds in the end zone as players passed it around hoping for a miracle touchdown. Altmyer was 12-of-26 passing for 249 yards and two touchdowns. Bryant finished with seven receptions for 197 yards.
