casino wolf of wall street KyKy Tandy scored a season-high 21 points that included a key 3-pointer in a late second-half surge as Florida Atlantic roared back to beat Oklahoma State 86-78 on Thursday in the opening round of the Charleston Classic in Charleston, S.C. Florida Atlantic (4-2) advances to play Drake in the semifinal round on Friday while the Cowboys square off against Miami in the consolation semifinal contest, also Friday. Oklahoma State led by as many as 10 points in the first half before securing a five-point advantage at halftime. The Owls surged back and moved in front with four and a half minutes to play. It was part of an 11-1 run, capped by a 3-pointer from Tandy that made it 75-68 with 2:41 remaining. Ken Evans added 14 points for Florida Atlantic, with Leland Walker hitting for 13 and Tre Carroll scoring 11. The Owls went 35-of-49 from the free throw line as the teams combined for 56 fouls in the game, 33 by Oklahoma State. Khalil Brantley led Oklahoma State (3-1) with 16 points while Robert Jennings added 14 points and 11 rebounds for the Cowboys, who hit one field goal over a 10-minute stretch of the second half while having three players foul out. The Owls were up by as many as seven points in the early minutes and by 13-10 after a layup by Carroll at the 11:32 mark of the first half. Oklahoma State leapfrogged to the front on Abou Ousmane's layup off a Brantley steal, fell behind again on a 3-pointer by Evans and then responded on a 3-pointer by Jennings to take a 17-16 lead. From there, the Cowboys stoked their advantage to double digits when Jamyron Keller canned a shot from beyond the arc with five minutes to play in the half. Florida Atlantic got a layup and a monster dunk from Matas Vokietaitis and a pair of free throws from Walker in a 6-2 run to end the half to pull within 39-34 at the break. Jennings and Ousmane tallied seven points apiece for Oklahoma State over the first 20 minutes, as the Cowboys led despite shooting just 33.3 percent from the floor in the half. Carroll and Vokietaitis scored seven points apiece to pace the Owls, who committed 11 turnovers that translated to seven points for Oklahoma State before halftime. --Field Level Media

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WILMETTE, Ill., Dec. 05, 2024 (GLOBE NEWSWIRE) -- Monopar Therapeutics Inc. (Nasdaq: MNPR), a clinical-stage biotechnology company focused on developing innovative treatments for patients with unmet medical needs, today announced the first patient ever dosed with MNPR-101-Lu. This novel therapeutic radiopharmaceutical combines MNPR-101, Monopar’s antibody that selectively targets the urokinase plasminogen activator receptor (uPAR), with the therapeutic radioisotope lutetium-177. uPAR is involved in tumor growth and metastasis, and is found in some of the most aggressive, deadly cancers, including pancreatic, ovarian, triple negative breast, and colorectal cancers. The MNPR-101-Lu intravenous infusion was well-tolerated with no serious adverse reactions reported. This patient, dosed under a compassionate use protocol in the US, has metastatic pancreatic cancer, and prior to dosing, the cancer was imaged using MNPR-101-Zr (a zirconium-89 imaging radioisotope conjugated to MNPR-101) with a PET/CT scanner and showed uPAR expression. “As a result of encouraging biodistribution and dosimetry clinical data we recently reported ( link ) with our radiodiagnostic, MNPR-101-Zr, we have been eagerly looking forward to initiating treatment of patients with MNPR-101-Lu, hopeful it may provide an important therapeutic benefit to a group of cancer patients very much in need,” said Chandler Robinson, MD, Monopar’s Chief Executive Officer. “We are thrilled to have dosed this patient with MNPR-101-Lu, and believe this may be the world’s first dosing of a patient with a uPAR-targeted therapeutic radiopharmaceutical,” said Andrew Cittadine, Monopar’s Chief Operating Officer. Monopar is actively enrolling participants in two Phase 1 clinical studies in Australia, evaluating MNPR-101-Zr for imaging and MNPR-101-Lu for treatment of advanced solid tumors. Further information about the MNPR-101-Lu Phase 1a trial is available at www.ClinicalTrials.gov under study identifier NCT06617169 . Further information about the MNPR-101-Zr Phase 1 imaging and dosimetry clinical trial is available at www.ClinicalTrials.gov under study identifier NCT06337084 . About Monopar Therapeutics Inc. Monopar Therapeutics is a clinical-stage biotechnology company with ALXN-1840 for Wilson disease which has completed a Phase 3 trial, and radiopharma programs including Phase 1-stage MNPR-101-Zr for imaging advanced cancers, and Phase 1a-stage MNPR-101-Lu and late preclinical-stage MNPR-101-Ac225 for the treatment of advanced cancers. For more information, visit: www.monopartx.com . Forward-Looking Statements Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. The words “may,” “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “target” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Examples of these forward-looking statements include statements concerning: the MNPR-101-Lu intravenous infusion was well-tolerated with no serious adverse reactions reported; that as a result of recently reported encouraging biodistribution and dosimetry clinical data with Monopar’s radiodiagnostic, MNPR-101-Zr, the Company has been eagerly looking forward to initiating treatment and to seeing if the Company can bring an important therapeutic benefit to a group of cancer patients very much in need; and the Company believes this may be the world’s first dosing of a patient with a uPAR-targeted therapeutic radiopharmaceutical. The forward-looking statements involve risks and uncertainties including, but not limited to: that the patient may develop a serious adverse event in the future to MNPR-101-Lu; that radiation dosimetry analytics in the future may not be consistent with the estimated data generated thus far; that Monopar may not find enough patients to successfully enroll its MNPR-101-Lu therapeutic study; that the Phase 1 imaging and dosimetry clinical trial in advanced cancer patients with MNPR-101-Zr may not yield consistently satisfactory results; that future preclinical or clinical data may not be as promising as the data to date; that MNPR-101-Zr and/or MNPR-101-Lu may cause unexpected serious adverse effects or fail to be effective against the cancer tumors in humans; that the trials could result in a clinical hold should there be a Serious Adverse Event; Monopar’s ability to raise sufficient funds in order for the Company to support continued clinical, regulatory and commercial development of its programs and to make contractual future milestone payments, as well as its ability to further raise additional funds in the future to support any future product candidate programs through completion of clinical trials, the approval processes and, if applicable, commercialization; uncertainties related to the regulatory discussions that Monopar intends to initiate related to ALXN-1840 and the outcome thereof; the rate of market acceptance and competitiveness in terms of pricing, efficacy and safety, of any products for which Monopar receives marketing approval, and Monopar’s ability to competitively market any such products as compared to larger pharmaceutical firms; and the significant general risks and uncertainties surrounding the research, development, regulatory approval, and commercialization of imaging agents and therapeutics. Actual results may differ materially from those expressed or implied by such forward-looking statements. Risks are described more fully in Monopar's filings with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. Monopar undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made. Any forward-looking statements contained in this press release represent Monopar’s views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date. CONTACT: Monopar Therapeutics Inc. Investor Relations Karthik Radhakrishnan Chief Financial Officer karthik@monopartx.com Follow Monopar on social media for updates: Twitter: @MonoparTx LinkedIn: Monopar TherapeuticsIslam is a unifying thread across the Muslim world, but its practice and interpretation vary widely based on historical, cultural and political contexts. Saudi Arabia and Afghanistan offer starkly contrasting perspectives on Islam, reflecting their unique journeys through conservatism, modernisation and fundamentalism. While Saudi Arabia attempts to reconcile its strict Wahhabi roots with a modern, globalised identity, Afghanistan under Taliban rule clings to a regressive and rigid interpretation of Islamic law, particularly in its treatment of women. Saudi Arabia: Evolving Beyond Narrow Wahhabism For much of its modern history, Saudi Arabia has been synonymous with Wahhabism, a puritanical branch of Sunni Islam. Established in the 18th century as part of a pact between the Wahhabi movement and the Al-Saud family, this ideology shaped the Kingdom’s laws and social norms. Strict dress codes, gender segregation and the absence of cultural entertainment were defining characteristics. The discovery of oil in 1938 transformed Saudi Arabia into a global economic powerhouse but did little to alter its conservative social fabric. Women were forbidden from driving until 2018, religious police patrolled public spaces to enforce Islamic norms and live music and cinema were banned. This changed dramatically under Crown Prince Mohammed bin Salman’s Vision 2030, a reform agenda aimed at diversifying the economy and projecting a modern, progressive image of Saudi Arabia. Today, the Kingdom hosts concerts, fashion shows and sporting events that would have been unimaginable a decade ago. Saudi women now drive, work in various industries and travel without male guardianship. These reforms reflect a society grappling with its dual identity: a modern state vying for global influence and an Islamic society rooted in tradition. However, this transformation is not without contradictions. While Riyadh dazzles with events featuring global stars like Céline Dion and Jennifer Lopez, the Kingdom continues to uphold one of the harshest justice systems in the world. Mass executions, particularly of foreign nationals, reveal a darker side of its governance, underscoring the tension between progress and repression. Qazi Faez Isa And Islam - Part II Afghanistan: The Grip of Taliban Fundamentalism In contrast to Saudi Arabia’s evolving interpretation of Islam, Afghanistan under the Taliban remains firmly entrenched in a regressive, fundamentalist ideology. The Taliban’s version of Islam, heavily influenced by Deobandi principles and Wahhabi teachings, emerged from decades of conflict and foreign intervention. During the 1980s, Saudi Arabia played a significant role in funding madrassas along the Afghan-Pakistan border, which indoctrinated young men with conservative Islamic teachings. These madrassas served as a breeding ground for the Taliban, whose rise to power in the 1990s marked a dark period for Afghan women and minorities. Saudi Arabia’s path forward lies in balancing its conservative Islamic roots with the demands of a modern state. The Kingdom’s reforms are driven by necessity, as it seeks to diversify its economy and attract global investment Since regaining control in 2021, the Taliban have reinstated draconian laws that systematically exclude women from public life. Girls are banned from attending schools and universities, women cannot work in government institutions or businesses and they are prohibited from appearing in media or even visiting parks without a male guardian. These policies not only violate basic human rights but also contrast sharply with the relative progress seen in other Muslim-majority countries, including Saudi Arabia. Women’s Rights: A Tale of Two Realities The status of women offers a stark lens through which to compare Saudi Arabia and Afghanistan. Women in Saudi Arabia have gained unprecedented freedoms in recent years. They can now pursue higher education, work in diverse industries and participate in public life. However, cultural conservatism still imposes limits and full equality remains a distant goal. Under Taliban rule, Afghan women face unparalleled restrictions. They are effectively erased from public life and denied education, employment and the freedom to move independently. This is a severe divergence from Islamic teachings that emphasise education and respect for women. From Art To Algorithm: Social Media And The Death Of Culture, Society The influence of Wahhabism, exported by Saudi Arabia in the late 20th century, has shaped the ideological framework of groups like the Taliban. Yet, while Saudi Arabia has moved toward moderation and modernity, Afghanistan has doubled down on rigid fundamentalism. Saudi Arabia’s Vision 2030 reflects an acknowledgment that economic growth and global engagement require a more inclusive society. Afghanistan, in contrast, remains isolated, with its rulers prioritising ideological purity over progress. Saudi Arabia’s path forward lies in balancing its conservative Islamic roots with the demands of a modern state. The Kingdom’s reforms are driven by necessity, as it seeks to diversify its economy and attract global investment. Its evolving interpretation of Islam may inspire other Muslim-majority nations to explore similar pathways. Afghanistan, however, faces a grimmer future. The Taliban’s refusal to adapt to the changing world not only isolates the country but also perpetuates suffering for its people, particularly women. The global community’s challenge lies in finding ways to support Afghan civil society while addressing the Taliban’s oppressive policies. The stories of Saudi Arabia and Afghanistan underscore the diversity of Islam and its interpretations. While both nations have been shaped by conservative ideologies, their trajectories could not be more different. Saudi Arabia’s embrace of reform signals hope for a more inclusive future, while Afghanistan’s descent into fundamentalism highlights the dangers of ideological rigidity. For the Muslim world, these contrasting paths serve as a reminder that Islam’s essence is not monolithic but adaptable to the needs and aspirations of its followers. The choices made by leaders and societies will determine whether Islam is a force for progress or a tool of oppression in the 21st century.

New Orleans police arrest man accused of killing paradegoers during multiple mass shootingsAs China continues to assert its influence and control over the region, it faces a delicate balancing act of safeguarding its national interests while also maintaining stability and cooperation with neighboring countries. The latest restrictions imposed by the PLA on coastal airspace have underscored the complexities and challenges of managing territorial disputes and security concerns in the Asia-Pacific region.